Journal Papers




  1. Fu-Erh Chan, Huei-Min Syu, Te-Yi Wang, Zheng-Ting Tang, Chih-Ning Huang, Jyh-Fu Lee, Thierry Burnouf, Shang-Hsiu Hu, Po-Chun Chen, Wei-Chen Huang, Iridium Oxide Nanoparticle–Protein Corona Neural Interfaces with Enhanced Electroactivity and Bioactivity Enable Electrically Manipulatable Physical and Chemical Neuronal Activation, Adv. Mater. Interfaces 2021, 8, 2100694. (Journal Cover) 

  2. Bhanu Nirosha Yalamandala, Wei-Ting Shen, Sheng-Hao Min, Wen-Hsuan Chiang, Shing-Jyh Chang, Shang-Hsiu Hu*, Advances in Functional Metal-Organic Frameworks-Based On-Demand Drug Delivery Systems for Tumor Therapeutics, Advanced NanoBiomed Research, 2021, 2100014. (Invited review, Journal Cover) 

  3. Wei-Ting Shen, Ru-Siou Hsu, Jen-Hung Fang, Pei-Fen Hu, Chi-Shiun Chiang, Shang-Hsiu Hu*, Marginative Delivery-Mediated Extracellular Leakiness and T Cell Infiltration in Lung Metastasis by Biomimetic Nano-Raspberry, Nano Letters, 2021, 21, 1375–1383.  (Journal Cover)

  4. Min-Ren Chiang, Yu-Lin Su, Chih-Yi Chang, Chein-Wen Chang, Shang-Hsiu Hu*, Lung metastasis-targeted donut-shaped nanostructures shuttled by the margination effect for the PolyDox generation-mediated penetrative delivery into deep tumors, Materials Horizons, 2020, 7, 1051. (Journal Cover)

  5. Jen-Hung Fang, Hao-Hsiang Hsu, Ru-Siou Hsu, Chih-Kang Peng, Yu-Jen Lu, You-Yin Chen, San-Yuan Chen*, Shang-Hsiu Hu*, 4D Printing of Stretchable Nanocookie@Conduit Hosting Biocues and Magneto-Electrical Stimulation for Neurite Sprouting, NPG Asia Materials, 2020,12, 61.  

  6. Ru-Siou Hsu, Jen-Hung Fang, Wei-Ting Shen, Yu-Chen Sheu, Cheng-Kuan Su, Wen-Hsuan Chiang, Shang-Hsiu Hu*, DNA-Architected Nano-Raspberry Depot-Mediated On-Demand Programmable Refilling and Release Drug Delivery, Nanoscale, 2020,12, 11153.

  7. Yu-Lin Su, Li-Wen Kuo, Chia-Hsien Hsu, Chi-Shiun Chiang, Yu-Jen Lu, Shing-Jyh Chang, Shang-Hsiu Hu*, Rabies virus glycoprotein-amplified hierarchical targeted hybrids capable of magneto-electric penetration delivery to orthotopic brain tumor, J. Control. Release, 2020, 321, 159. 

  8. Jen-Hung Fang, Che-Hau Liu, Ru-Siou Hsu, Yin-Yu Chen, Wen-Hsuan Chiang, Hui-Min David Wang, Shang-Hsiu Hu*, Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment, Polymers, 2020, 12, 1392. (Feature Paper; Editor's Choice Article;Invited paper)

  9. Min-Cong Xiao, Ya-Hsuan Chou, Yu-Ning Hung, Shang-Hsiu Hu, Wen-Hsuan Chiang*, Hybrid polymeric nanoparticles with high zoledronic acid payload and proton sponge-triggered rapid drug release for anticancer applications, Materials Science & Engineering C, 2020, 116, 111277. 

  10. Hsing-Yu Haung, Yi-Chen Wang, Ying-Chen Cheng, Wenyi Kang, Shang-Hsiu Hu, Dengyong Liu, Chaogeng Xiao, Hui-Min D. Wang*,  A novel oral astaxanthin nanoemulsion from Haematococcus pluvialis induces apoptosis in lung metastatic melanoma", Oxidative Medicine and Cellular Longevity, 2020, Volume 2020, Article ID 2647670. 

  11. Ru-Siou Hsu, Pei-Yueh Chen, Jen-Hung Fang, You-Yin Chen, Chien-Wen Chang, Yu-Jen Lu*, Shang-Hsiu Hu*, Adaptable Microporous Hydrogels of Propagating NGF-Gradient by Injectable Building Blocks for Accelerated Axonal Outgrowth, Advanced Science, 2019, 6, 1900520. 

  12. Shou-Yuan Sung, Yu-Lin Su, Wei Cheng, Pei-Feng Hu, Chi-Shiun Chiang, Wen-Ting Chen, Shang- Hsiu Hu*, Graphene Quantum Dots-Mediated Theranostic Penetrative Delivery of Drug and Photolytics in Deep Tumors by Targeted Biomimetic Nanosponges, Nano Letters, 2019, 19, 69.

  13. Yu-Lin Su, Shang-Hsiu Hu*, Functional Nanoparticles for Tumor Penetration of Therapeutics. Pharmaceutics, 2018, 10, 193. (Invited review) 

  14. Hoon Choi, Ting Liu, Hui Qiao, Ann-MarieChacko, Shang-Hsiu Hu, San-Yuan Chen, Rong Zhou, I-Wei Chen, Biomimetic nano-surfactant stabilizes sub-50 nanometer phospholipid particles enabling high paclitaxel payload and deep tumor penetration, Biomaterials, 2018, 181, 240. 

  15. Yu-Lin Su, Ting-Wei Yu, Wen-Hsuan Chiang, Hsin-Cheng Chiu, Chun-Hsiang Chang, Chi-Shiun Chiang, Shang-Hsiu Hu*, Hierarchically Targeted and Penetrated Delivery of Drugs to Tumors by Size-Changeable Graphene Quantum Dot Nanoaircrafts for Photolytic Therapy, Adv. Funct. Mater., 2017, 27, 1700056. 

  16. Yu-Lin Su, Kuan-Ting Chen, Yu-Chen Sheu, Shuo-Yuan Sung, Ru-Siou Hsu, Chi-Shiun Chiang, Shang-Hsiu Hu*, The Penetrated Delivery of Drug and Energy to Tumors by Lipo-Graphene Nanosponges for Photolytic Therapy, ACS Nano, 2016, 10, 9420. 

  17. Yu-Wei Chen, Yu-Lin Su, Shang-Hsiu Hu*, San-Yuan Chen*, Functionizalized Graphene Nanocomposites for Enhancing Photothermal Therapy, Advanced Drug Delivery Reviews, 2016, 105, 190. 

  18. I-Chieh Lin, Jen-Hung Fang, Chien-Ting Lin, Shou-Yuan Sung, Yu-Lin Su, Shang-Hsiu Hu*, Enhanced Targeted Delivery of Cyclodextrin-based Supermolecules by Core-Shell Nanocapsules for Magneto-thermal Chemotherapy, Macromolecular Bioscience, 2016, 16, 1273. (Journal Cover)

  19. Chien-Ting Lin, I-Chieh Lin, Shou-Yuan Sung, Yu-Lin Su, Yu-Fen Huang, Chi-Shiun Chiang, Shang-Hsiu Hu*, Dual Targeted Photo-penetrated Delivery of Multiple Micelles/Hydrophobic Drugs by a Nanopea for Enhanced Tumor Therapy, Adv. Funct. Mater., 2016, 26, 4169. (IF=15.621)

  20. Srivardhan Reddy Gayam, Parthiban Venkatesan, Yi-Ming Sung, Shou-Yuan Sung, Shang-Hsiu Hu, Hsin-Yun Hsu, Shu-Pao Wu, NAD(P)H: quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles for tumor targeted drug delivery in vitro and in vivo. Nanoscale, 2016, in press. 

  21. Ting-Wei Yu, I.-Lin Lu, Wen-Chia Huang, Shang-Hsiu Hu, Chia-Chian Hung, Wen-Hsuan Chiang, Hsin-Cheng Chiu, Acidity-triggered surface charge neutralization and aggregation of functionalized nanoparticles for promoted tumor uptake,  RSC Adv., 2016, 6, 36293. 

  22. Jen-Hung Fang, Tsung-Lang Chiu, Wei-Chen Huang, Yen-Ho Lai, Shang-Hsiu Hu, You-Yin Chen, and San-Yuan Chen, Dual-Targeting Lactoferrin-Conjugated Polymerized Magnetic Polydiacetylene-Assembled Nanocarriers with Self-Responsive Fluorescence/Magnetic Resonance Imaging for In Vivo Brain Tumor Therapy, Adv. Healthcare Mater., 2016, 5, 688.

  23. Yu-Lin Su, Jen-Hung Fang, Chia-Ying Liao, Chein-Ting Lin, Yun-Ting Li, Shang-Hsiu Hu*, Targeted Mesoporous Iron Oxide Nanoparticles-Encapsulated Perfluorohexane and a Hydrophobic Drug for Deep Tumor Penetration and Therapy, Theranostics, 2015, 5, 1233.  (Journal Cover)

  24. Jen-Hung Fang, Yun-Ting Li, Wen-Hsuan Chiang, Shang-Hsiu Hu*, Magnetoresponsive Virus-Mimetic Nanocapsules with Dual Heat-Triggered Sequential-Infected Multiple Drug-Delivery Approach for Combinatorial Tumor Therapy, Small, 2015, 11, 2417. 

  25. Chia-Wei Su, Chih-Sheng Chiang, Wei-Ming Li, Shang-Hsiu Hu, San-Yuan Chen, Multifunctional nanocarriers for simultaneous encapsulation of hydrophobic and hydrophilic drugs in cancer treatment, Nanomedicine, 2014, 9, 1499-1515.(Invited review)

  26. Shang-Hsiu Hu, Ren-Hong Fang, Yu-Wei Chen, Bang-Jie Liao, I-Wei Chen, San-Yuan Chen, Photo-Responsive Protein-Graphene-Protein Hybrid Capsules with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy, Adv. Funct. Mater., 2014, 24, 4144. 

  27.   Jen-Hung Fang, Yen-Ho Lai, Tsung-Lang Chiu, You-Yin Chen, Shang-Hsiu Hu*, San-Yuan Chen*, Magnetic Core/Shell Nanocapsules with Dual Targeting Capabilities and Co-Delivery of Multiple Drugs to Treat Brain Gliomas, Adv. Healthcare Mater. 2014, 3, 1250.

  28.  Shang-Hsiu Hu, Tsung-Ying Hsieh, Chin-Sheng Chiang, Po-Jung Chen, You-Yin Chen, Tsung-Lang Chiu, San-Yuan Chen, Surfactant-Free, Lipo-Polymersomes Stabilized by Iron Oxide Nanoparticles/Polymer Interlayer for Synergistically Targeted and Magnetically Guided Gene Delivery, Adv. Healthcare Mater. 2014, 3, 273.

  29.  Heng-Wen Liu, Wei-Chen Huang, Chih-Sheng Chiang, Shang-Hsiu Hu, Chia-Hsin Liao, You-Yin Chen, San-Yuan Chen, Arrayed rGOSH/PMASH Microcapsule Platform Integrating Surface Topography, Chemical Cues, and Electrical Stimulation for Three-Dimensional Neuron-Like Cell Growth and Neurite Sprouting, Adv. Funct. Mater., 2014, 24, 3715. 

  30.   Yu-Wei Chen, Po-Jung Chen, Shang-Hsiu Hu, I-Wei Chen, San-Yuan Chen, NIR-Triggered Synergic Photo-chemothermal Therapy Delivered by Reduced Graphene Oxide/Carbon/Mesoporous Silica Nanocookies, Adv. Funct. Mater., 2014, 24, 451-459.

  31.   Chih-Sheng Chiang, Shang-Hsiu Hu, Bang-Jie Liao, Yuan-Ching Chang, San-Yuan Chen, Enhancement of cancer therapy efficacy by trastuzumab-conjugated and pH-sensitive nanocapsules with the simultaneous encapsulation of hydrophilic and hydrophobic compounds, Nanomedicine: Nanotechnology, Biology, and Medicine, 2014, 10, 99-107.

  32.   Hsin-Yang Huang, Shang-Hsiu Hu, Shih-Ya Hung, Chih-Sheng Chiang, Hao-Li Liu, Tsung-Lang Chiu, Hsin-Yi Lai, You-Yin Chen, San-Yuan Chen, SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release formagnetically guided in vivo tumor therapy, Journal of Controlled Release, 2013, 172, 118–127.




  1. Shang-Hsiu Hu, Bang-Jie Liao, Chin-Sheng Chiang, Po-Jung Chen, I-Wei Chen, and San-Yuan Chen, Core-shell Nanocapsules Stabilized by Single-Component Polymer and Nanoparticles for Magneto-Chemotherapy-Hyperthermia with Multiple Drugs, Adv. Mater., 2012, 24, 3627. 

  2. Heng-Wen Liu, Shang-Hsiu Hu, Yu-Wei Chen and San-Yuan Chen, Characterization and drug release behavior of highly responsive chip-like electrically modulated reduced graphene oxide–poly(vinyl alcohol) membranes, J. Mater. Chem., 2012, 22, 17311.

  3. Shang-Hsiu Hu, San-Yuan Chen, and Xiaohu Gao, Multifunctional nanocapsules for simultaneous encapsulation of hydrophilic and hydrophobic compounds and on-demand release, ACS Nano, 2012, 6, 2558. 

  4. Shang-Hsiu Hu, Yu-Wei Chen, Wen-Ting Hung, I-Wei Chen, and San-Yuan Chen, Quantum-Dot-Tagged Reduced Graphene Oxide Nanocomposites for Bright Fluorescence Bioimaging and Photothermal Therapy Monitored In Situ, Adv. Mater., 2012, 24, 1748.

  5. Hsin-Yang Huang, Shang-Hsiu Hu, Chih-Shang Chian, San-Yuan Chen, Hsin-Yi Lai and You-Yin Chen, Self-assembling PVA-F127 thermosensitive nanocarriers with highly sensitive magnetically-triggered drug release for epilepsy therapy in vivo, J. Mater. Chem., 2012, 22, 8566.

  6. Po-Jung Chen, Shang-Hsiu Hu, Wen-Ting Hung, San-Yuan Chen and Dean-Mo Liu, Geometrical confinement of quantum dots in porous nanobeads with ultraefficient fluorescence for cell-specific targeting and bioimaging J. Mater. Chem., 2012, 22, 9568.

  7. Shang-Hsiu Hu, You-Yin Chen, Ta-Chung Liu, Tsan-Hua Tung, Dean-Mo Liu, and San-Yuan Chen, Remotely nano-rupturable yolk/shell capsules for magnetically- triggered drug release, Chem. Commun., 2011, 47, 1776.

  8. Po-Jung Chen, Shang-Hsiu Hu, Chi-Sheng Hsiao, You-Yin Chen, Dean-Mo Liu and San-Yuan Chen, Multifunctional magnetically removable nanogated lids of Fe3O4–capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging, J. Mater. Chem., 2011, 21, 2535.

  9. Wei-Lin Tung, Shang-Hsiu Hu, Dean-Mo Liu, Synthesis of nanocarriers with remote magnetic drug release control and enhanced drug delivery for intracellular targeting of cancer cells, Acta Biomater., 2011, Article in press.




  1. Shang-Hsiu Hu, and Xiaohu Gao, "Nanocomposites with Spatially Separated Functionalities for Combined Imaging and Magnetolytic Therapy", J. Am. Chem. Soc., 2010, 132, 7234-7237. 

  2. Shang-Hsiu Hu, and Xiaohu Gao, "Stable Encapsulation of QD Barcodes with Silica Shells", Adv. Func. Mat., 2010, 20, 3721. 




  1. Kuan-Ting Kuo, Shang-Hsiu Hu, Dean-Mo Liu, and San-Yuan Chen. Magnetically-induced Synthesis of Highly-Crystalline Ternary Semiconductor Chalcopyrite Nanocrystals via a Magnetic Doping at Ambient Conditions, Journal of Materials Chemistry, 2010, 20, 1744-1750. 

  2. Shang-Hsiu Hu, Kuan-Ting Kuo, Wei-Lin Tung, Dean-Mo Liu, and San-Yuan Chen. Synthesis of Drug Delivery Nano-device capable of Imagining, Targeting, and Self-Monitoring of Drug Release in Cancerous Cells, Adv. Func. Mat., 2009, 19, 3396. 

  3. Wei-Chen Huang, Shang-Hsiu Hu, Kun-Ho Liu, San-Yuan Chen and Dean-Mo Liu. A Flexible Drug Delivery Chip for Magnetically-Controlled Release of Anti-Epileptic Drug, Journal of Controlled Drug Release, 2009, 139, 221-228.

  4. Ting-Yu Liu, Shang-Hsiu Hu, Dean-Mo Liu, San-Yuan Chen, and I-Wei Chen, Biomedical Nanoparticle Carriers with Combined Thermal and Magnetic Responses, NanoToday, 2009, 4, 52-69 ( invited review). 
    Shang-Hsiu Hu, Ting-Yu Liu, Hsin-Yang Huang, Dean-Mo Liu, and San-Yuan Chen, Stimuli-Responsive Controlled Drug Release from Magnetic-Sensitive Silica Nanospheres, J. Nanosci. Nanotechnol., 2009, 9, 866-870.

  5. Shang-Hsiu Hu, Chia-Hui Tsai, Chen-Fu Liao, Dean-Mo Liu and San-Yuan Chen, Controlled Rupture of Magnetic Polyelectrolyte Microcapsules for Drug Delivery, Langmuir, 2008, 24, 11811–11818. 

  6. Shang-Hsiu Hu, Wei-Lin Tung, Chen-Fu Liao, Dean-Mo Liu and San-Yuan Chen, Surfactant-free, Self-Assemble PVA-Iron Oxide /Silica Core-Shell Nanocarriers for High-Sensitive Magnetically Controlled Drug Release and Ultra-high Cancer Cell Uptake Efficiency, Adv. Func. Mat., 2008, 18, 2946-2955.

  7. Shang-Hsiu Hu, San-Yuan Chen, Chi-Sheng Hsiao and Dean-Mo Liu, “Core/Single-Crystal-Shell Nanospheres for Controlled Drug Release via a Magnetically Triggered Rupturing Mechanism”, Adv. Mat., 2008, 20, 2690-2695.

  8. Ting-Yu Liu, Shang-Hsiu Hu, Kun-Ho Liu, Dean-Mo Liu and San-Yuan Chen, Instantaneous Drug Delivery of Magnetic/Thermal Sensitive Nanospheres by a High Frequency Magnetic Field, Langmuir, 2008, 24, 13306-13311.

  9. Ting-Yu Liu, Shang-Hsiu Hu, Kun-Ho Liu, Dean-Mo Liu and San-Yuan Chen, “Study on controlled drug permeation of magnetic-sensitive ferrogels: Effect of Fe3O4 and PVA ”, Journal of Controlled Drug Release, 2008, 126, 228-236. 

  10. Shang-Hsiu Hu, Ting-Yu Liu, Hsin-Yang Huang, Dean-Mo Liu and San-Yuan Chen, “Magnetic-Sensitive Silica Nanospheres for Controlled Drug Release”, Langmuir, 2008, 23, 239.

  11. Ting-Yu Liu, Li-Ying Huang, Shang-Hsiu Hu, Ming-Chien Yang and San-Yuan Chen, Core-shell magnetic nanoparticles of heparin conjugate as recycling anticoagulants, J. Biomed. Nanotechnol., 2007, 7, 353.

  12. Shang-Hsiu Hu, Ting-Yu Liu, Dean-Mo Liu and San-Yuan Chen, “Controlled Pulsatile Drug Release from a Ferrogel by a High-Frequency Magnetic Field”, Macromolecules, 2007, 40(19), 6786-6788. 

  13. Shang-Hsiu Hu, Ting-Yu Liu, Dean-Mo Liu and San-Yuan Chen, “Nano- Ferrosponges For Controlled Drug Release”, Journal of Controlled Drug Release, 2007, 121 (3), 181-189.

  14. Shang-Hsiu Hu, Ting-Yu Liu, Chia-Hui Tsai, Dean-Mo Liu and San-Yuan Chen, “Preparation and Characterization of magnetic ferroscaffolds for tissue engineering”, Journal of Magnetism and Magnetic Materials, 2007, 310(2), 2871-2873. 

  15. Ting-Yu Liu, Shang-Hsiu Hu, Sheng-Hsiang Hu, Szu-Ping Tsai and San-Yuan Chen, “Preparation and characterization of thermal-sensitive ferrofluids for drug delivery application ”, Journal of Magnetism and Magnetic Materials, 2007, 310 (2), 2850-2852. 

  16. Ting-Yu Liu, Shang-Hsiu Hu, Tse-Ying Liu, Dean-Mo Liu and San-Yuan Chen,” Magnetic-sensitive behavior of intelligent ferrogels for controlled release of drug,” Langmuir, 2006; 22(14); 5974-5978.

  17. Ting-Yu Liu, Hung-Chou Liao, Chin-Ching Lin, Shang-Hsiu Hu, and San-Yuan Chen, ” Bio-functional ZnO nanorods arrays grown on flexible substrates,” Langmuir; 2006; 22(13); 5804-5809. 

  18. Ting-Yu Liu, Shang-Hsiu Hu, Kun-Ho Liu, Dean-Mo Liu, San-Yuan Chen, “Preparation and characterization of smart magnetic hydrogels and its use for drug release,” Journal of Magnetism and Magnetic Materials, 304, 2006, e397-e399.

  19. Jiang-Jen Lin, Shi-Min Chen, Shang-Hsiu Hu, ” Poly(oxyethylene) diamine- Derived Hydrophilic Copolymers for Emulsifying Diglycidylether of Bisphenol-A, ”Journal of Applied Polymer Science, Vol. 94, 1797–1802 (2004).


  1. K5P107033-TW (107B0193-I1)「含硼參雜石墨烯量子點的奈米複合物及其應用」,蘇昱璘、胡尚秀。美國、中華民國,2021 獲證。

  2. K5P107042-TW「可注射型自組裝微球凝膠、其用途及可注射型自組裝微球凝膠的製備方法」,許如秀、胡尚秀,2018,美國、中華民國。Pending 

  3. K5P107033-US (107F0260-IE)「仿狂犬病毒之樹狀高分子/石墨烯量子點奈米載體應用於腦瘤穿透治療」,美國專利 申請號:16/239,963,申請日:2019/01/04。2020/12/09 美國獲證。證 書 號:US 10,894,020

  4. 專利權起訖日:2021年1月19日起至2039年1月4日止

  5. K5P104004(103F0683-IE)「用於藥物傳遞的蛋白質納米磁性殼核膠囊及其應用」大陸專利獲證, 2019年 03月 13日。


Book Chapter

  1. l San-Yuan Chen, Shang-Hsiu Hu, Ting-Yu Liu, “Magnetic-responsive Nanoparticles for Drug Delivery”, RSC Book Smart Materials for Drug Delivery, RSC Publicaiton/Wiley, 2012.

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